Recently, the importance of mental health has hit high on the agenda, as more people talk about the issues they have beyond the surface and the stigma of maintaining your mental wellbeing has reduced through increased awareness.
One of the most severe forms of anxiety disorders is PTSD, and it’s estimated that around 3% of people will experience it at some point during their life.
While there is a bank of growing evidence of people using marijuana to improve their mental health, this has focused on the benefits of THC.
Historically, academic research in cannabis has focused on deciphering the potential benefits along with misgivings of THC – the compound found in marijuana responsible for the cannabis high.
It’s now becoming more evident that cannabis contains non-intoxicating compounds which are of potential therapeutic interest for both academics and consumers.
One of these is cannabidiol, also known as CBD. It’s a non-intoxicating compound found in the cannabis family of plants and is the main constituent in CBD oils.
Scientific interest in the use of CBD for PTSD anxiety is an area currently under exploration, and while it’s early, there are some compelling pre-clinical results to discuss.
But before we proceed, you might have one question on your mind:
Post Traumatic Stress Disorder (PTSD) is an anxiety disorder caused by extremely distressing, frightening or stressful events which significantly impact an individual’s mental health. It can even occur from learning that the trauma happened to someone else.
After an individual goes through a distressing event, it’s normal to feel anxious and experience thoughts of negativity. It’s only if after an extended period these symptoms worsen and compounds it turns into PTSD.
The condition can lead to changes in mental health, including flashbacks, nightmares, mood/sleep pattern changes and emotional withdrawal. Further to this, complex PTSD can develop years after the event, leading to confusion and a lack of self-belief behind the trigger.
While PTSD is mostly associated with war veterans and military personnel, the disorder can affect anyone who has gone through or learned of a significant amount of trauma, either physical or psychological.
Traumatic events may include serious road traffic accidents, domestic abuse, memories of war, physical or sexual assault, but it can be anything which someone finds highly traumatic.
Statistically, some people are significantly more at risk of experiencing PTSD in their life, including:
University College London recently conducted a systematic review of the use of cannabinoids in the treatment of PTSD, using participant notes about the use of cannabis (derived from previous studies).
The review consisted of previous 10 studies, and while the analysis didn’t look at the cannabinoids individually, they concluded that more research is needed as the evidence presented showed promise. Still, it wasn’t clinical or of high quality.
Other studies have explicitly focused on the use of Cannabidiol and PTSD:
While both of the previously mentioned PTSD studies fall short of a double-blind clinical analysis, and there is a lot of work to do, they do suggest there is a need to further explore the use of CBD oil for post-traumatic stress disorder.
Fortunately, there are currently two human-based trials already underway which examine the use of CBD along with THC for PTSD.
This includes a triple-blind clinical trial of 42 participants using high THC marijuana as a treatment for PTSD, in addition to another similar clinical trial of 80 war veterans, using varying strengths of cannabis to ease the symptoms of PTSD, including high CBD cannabis.
These PTSD trials are expected to be published in 2022. They are what’s needed to move the needle forward to come to a research conclusion for the use of cannabidiol for PTSD outside of anecdotal evidence.
Additionally, as PTSD is classed as a severe anxiety disorder in the UK, other more complex research grants issued in 2019 to explore the broader use of CBD for anxiety could provide beneficial background information. The results of these types of studies are expected to be published sometime in 2020 or 2021.
Cannabinoids such as CBD are processed through our endocannabinoid system (ECS), by interacting with two cannabinoid receptors called CB1 and CB2.
Research indicates these interactions with these receptors is partially responsible for emotional memory processing, which is associated with the problems suffers of PTSD can have with negative memories.
Scientists believe that by blocking the back to back retrieval of these memories, the endocannabinoid system is thought to help with both the emotional and cognitive issues associated with PTSD by reducing anxiety in line with suppression of the traumatic event triggering the PTSD.
Broader research on the uses of CBD aligns with this hypothesis, with multiple studies suggesting the compound has potential anxiolytic effects. It’s also thought that as a direct consequence of reducing anxiety, it’s expected those suffering from poor mental health would sleep better and feel less distressed.
Current treatments for PTSD consist of psychological therapies, including:
The most common first line therapies also include psychiatric medications and antidepressants such as sertraline, paroxetine, SSRI’s, and mirtazepine. Nightmares are targeted using prazosin or topiramate to improve sleep. Benzodiazepines are generally avoided given the elevated risk of substance dependence.
Overall, CBD products are considered safe, but they do have a minor likelihood for drug interactions (in line with the grapefruit warning you see on some medications). So if you do use medication which has the grapefruit warning, it’s something to be indeed aware of and keep note. This may include common but important medications like blood thinners and blood pressure medications.
Nonetheless, it is important to always talk to your doctor for medical advice and to inform them of any changes you intend on making, including adding new supplements like CBD to your diet. If you have a pre-existing liver condition, your doctor may need to recheck liver enzymes.
No, CBD is a supplement to be added to your diet to boost your endocannabinoid system.
Nature & Bloom CBD is not a medicine and cannot treat, cure or prevent any disease.
Instead, look at CBD for PTSD as a daily vitamin you take to help regulate your ECS and keep all of your other systems in balance.
It’s clear more robust research is needed, and with larger sample sets to further understand how CBD interacts with the symptoms of PTSD.
The larger bank of evidence being compiled through studies like these will prove fruitful in furthering our understanding of CBD and other cannabinoids.
Either way, if you have or think you may have PTSD ensure you talk to a health professional to gain medical advice to obtain the most appropriate level of input.
Disclaimer: Views expressed here do not necessarily reflect those of Nature & Bloom and its staff. This article is for strictly informational purposes and is not intended to provide medical advice, diagnosis, treatment, cure or prevention for any disease. Nature & Bloom products have not been evaluated by the MHRA.